While it is not possible to change information on a DS-160 after it has been submitted, there are two easy options for creating a new DS-160.
If it is within 30 days from when the original application was submitted, the first option is to log into the Consular Electronic Application Center (CEAC) system and select “Retrieve an Application” using the application ID number. Next, you will be asked whether you want to go to the confirmation page or create a new application. Select create a new application, and the entire application will appear, except for travel plans to the U.S. Then, you will need to edit and update the information and submit again.
Alternatively, if you saved the DAT file from the original application, you can access and amend the information at any time from an already submitted application. Once the changes have been made, save and submit the new application.
For either option, if the original DS-160 was used to book the visa appointment or pay the MRV fee, the applicant MUST present at the interview the confirmation pages from the new AND original DS-160, as each submission creates a different barcode. AILA InfoNet Doc. No. 13011146 (posted Jan. 11, 2013)